姓名:賴吾為醫師
主要學歷

現職

經歷

專長

學術成大
學術論文

1. Lin CH, Tsai CH, Yeh CT, Liang JL, Hung WC, Lin FC, Chang WL, Li HY, Yao YC, Hsu TI, Lee YC, Wang YC, Sheu BS, Lai WW, Calkins MJ, Hsiao M, Lu PJ. 2016/05 MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma. Oncotarget. 7(26):39680-39693. (SCI. oncology, 36/213, 16.9%; Cell biology, 43/187, 22.99%. IF: 5.008, United States).

2. Yang SC, Lai WW, Hsiue TR, Su WC, Lin CK, Hwang JS, Wang JD. 2016/06, Health-related quality of life after first-line anti-cancer treatments for advanced non-small cell lung cancer in clinical practice. Quality of Life Research 25(6), 1441-1449. 2015 (SCI. Health care science & service 29/88, 32.95%; Public, environment & occupation 50/173, 28.9%. Impact Factor: 2.429, Netherland).

3. Kuo IY, Jen JY, Hsu LH, Hsu HS,  Lai WW*,  Wang YC*. 2016/08 A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.  J Biomed Scie.23:58. (SCI, Cell biology, 101/187, 54.04%; clinical medicine, 45/124, 36.29%. IF: 2.935. Taiwan,)

4. Hung MC, Lai WW, Chen HHW, Lee JC, Lin YJ, Hsiao JR, Cheng YM, Shan YS, Su WC, Wang JD. 2016/08 Cost-effectiveness analysis of cancer treatment in Taiwan. J. Formos. Med. Assoc 115(8);609-18. , (SCI. Medicine, general & internal.46/155, 29.67%, IF: 2.018, Taiwan)

5.  Wu WC, Tseng YL, Yen YT, Lai WW*. 2016/08. Feasibility of Surgery for Advanced NSCLC Treated With Tyrosine Kinase Inhibitors as Neoadjuvant Therapy. Thorac Med. 31(4);236-242. (IF: 0.5, Taiwan)

6. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC. 2016/11. Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res.23(9);2335–45.(SCI. Oncology 12/213: 5.63% IF: 8.738, United States)

7.  Min-hsin Huang, Chao-Han Lai,  Pin-I Lin, Wu-Wei Lai* 2017/02 Arterial lactate level is associated with mortality rate in unscheduled surgical intensive care admissions. Formosan journal of Surgery 50(1) 21-27. (非SCI, IF: 0.5, Taiwan)

8.  Lin CY, Yang SC, Lai WW, Su WC, Wang JD. 2017/03.Rasch models suggested the satisfactory psychometric properties of the World Health Organization Quality of Life-Brief among lung cancer patients. J Health Psychol. 2017 Mar;22(4):397-408. (SCI. psychology, clinical: 56/119: 47%. Impact Factor: 1.748, England,).

9.  Yang SC, Lai WW, Lin CC, Su WC, Ku LJ, Hwang JS, Wang JD.2017/04. Cost-effectiveness of implementing computed tomography screening for lung cancer in Taiwan. Lung Cancer 108:183-91. (SCI. Oncology 65/213, 30.5%; Respirology 12/58, 20.7%, IF: 3.767, Netherlands).

10. Chang WL*, Lai WW*, Kuo IY, Lin CY, Lu PJ, Sheu BS, Wang YC. 2017/06 A six-CpG panel with DNA methylation biomarkers predicting treatment response of chemoradiation in esophageal squamous cell carcinoma. J Gastroenterol. 52(6):705–714 (SCI. Gastroenterology & Hepatology 14/79, 17.7%, IF: 4.4, Japan ) Published online: 26 September 2016

11. Liao SY, Chiang CW, Hsu CH, Chen YT, Jen J, Juan HF, Lai WW  Wang YC. 2017/06. CK1δ/GSK3β/FBXW7αaxis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression. Oncogene 36,5722–5733 (SCI, Biochemistry & Molecular biology 24/289, 8.3%;; oncology, 15/213, 7.0%; cell biology 25/187, 13.3%; genetics & heredity 12/166, 7.2%,. IF: 7.932..England)

12.Jayu Jen, Yen-An Tang, Ying-Hung Lu, Che-Chung Lin, Wu-Wei Lai, Yi-Ching Wang, 2017/06. Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. Molecular Cancer 2017; 16(1):104.(SCI. IF: 7.77, oncology, 22/223, 9.8%. Biochemistry and molecular biology 27/293, 9.2%. England)

13. Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai, Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, Ruey-Hwa Chen. 2017/08. Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment. JOURNAL OF CLINICAL INVESTIGATION 127(8):2982-2997. Epub 2017 Jul 10. (SCI. IF: 13.25, medicine, research, and experimental. 4/133 , 3.0%, USA)

14. Jia-Ming Chang, Yi-Ting Yen, Chao-Chun Chang, Yau-Lin Tseng, Wu-Wei Lai, Kam-Hong Kam, 2017/08 Pull method percutaneous endoscopic gastrostomy using transnasal ultrathin endoscopy in head and neck cancer. ENDOSCOPY 2017; 49(8), E188-E189.(SCI. IF: 6.63, surgery, 5/200, 2.5%. Gastroenterology and hepatology. 11/80 , 13.7%.  Germany)

15. Hong-Tai Tzeng, Tsung-Hsin Li, Yen-An Tang, Chung-Han Tsai, Pei-Jung Frank Lu, Wu-Wei Lai, Chi-Wu Chiang, Yi-Ching Wang, 2017/12 Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget 2017; 8(65):108556-108570.(SCI, IF: 5.31, Oncology, 44/217, 20.2%. Cell biology. 48/190, 25.2%. USA)

16.Szu-Chun Yang, Chien-Chung Lin, Wu-Wei Lai, Sheng-Mao Chang, Jing-Shiang Hwang, Wu-Chou Su, Jung-Der Wang. 2018/02 Dynamic changes in quality of life after three first-line therapies for EGFR mutation-positive advanced non-small-cell lung cancer. Ther Adv Med Oncol. 2018/02. (SCI, IF: 6.23, oncology. 33/223, 14.1%. England)

17. Hong-Tai Tzeng  Ching-Chin Su  Chih-Peng Chang  Wu-Wei Lai  Wu-Chou Su  Yi-Ching Wang. 2018/05 .Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages towards tumor‐suppressing phenotype. Int. J. Cancer: 2018;143, 1753–1763. (SCI, IF: 7.36, oncology, 23/223, 10.31%, Switzerland)

18.Tzu-Hung Lin, Wei-Li Huang, Chao-Chun Chang, Yi-Ting Yen, Wu-Wei Lai, Yau-Lin Tseng, and Ying-Yuan Chen. 2018/08. Uniportal video-assisted thoracoscopic surgery lobectomy and segmentectomy for pulmonary sequestration. J Thorac Dis 2018;10(6):3722-3728. (SCI. IF: 1.80, respiratory system.47/60, 78.33%. Hong Kong)

19. Cho SH, Kuo IY, Lu PF, Tzeng HT, Lai WW, Su WC, Wang YC. 2018/08 Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.  Cell Death and Disease; 9:868. (SCI. IF: 5.64, cell biology. 41/190, 21.57%, England)

20.  Wang, YS, Tzeng, HT, Tsai, CH, Cheng, HC, Lai, WW, Liu, HS., Wang, YC.2018/09. VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function. Cancer Lett. 437, 79-88. (SCI. IF: 6.49, oncology. 29/223, 13.00%, Netherlands)

21.Po-Lan Su, Yi-Lin Wu, Wei-Yuan Chang, Chung-Liang Ho, Yau-Lin Tseng, Wu-Wei Lai, Wu-Chou Su, Chien-Chung Lin, and Szu-Chun Yang 2018/09. Preventing and treating brain metastases with three first-line EGFR-tyrosine kinase inhibitors in patients with EGFR mutation-positive advanced non-small cell lung cancer Ther Adv Med Oncol 2018, 10: 1 –11. (SCI. IF 6.23, oncology.33/223, 14.1%.  England)

22.  Book: Stage III: NSCLC case library. Ch. 2.Surgical intervention strategy in stage III lung cancer

台灣肺癌學會。台北市，臻呈文化行銷有限公司，2018/11. ISBN: 978 -986-95806-4-9

23.  賴吾為*. 運用實地稽核於資料品質提升. 2018/11. 醫療品質雜誌. 12, 6: 22-26

24.莊孟蓉、洪麗娟、賴吾為. e ICU白板建構之滿意度探討-南部某醫學中心加護病房. 2018/12. 寶建醫護與管理雜誌.15;1/2:25-38.

25.Wei-Chieh Lin, Chang-Wen Chen, Chin-Li Lu, Wu-Wei Lai, Min-Hsin Huang, Liang-Miin Tsai, Chung-Yi Li, Chao-Han Lai. 2019/01 The association between recent hospitalized COPD exacerbations and adverse outcomes after percutaneous coronary intervention: a nationwide cohort study. Int J Chron Obstruct Pulmon Dis;14:169-179.

26. Chung-Ying Lin, Jing-Shiang Hwang., Wen-Chung Wang., Wi-Wei Lai, Wu-Chou Su., Tzu-Yi Wu., Grace Yao.*,  Jung-Der Wang.* 2019/01. Psychometric evaluation of the WHOQOL-BREF, Taiwan version, across five kinds of Taiwanese cancer survivors: Rasch analysis and confirmatory factor analysis. Journal of the Formosan Medical Association. 118, 215e222. (SCI. IF: 2.45, medicine, general and internal. 42/155, 27.09%. Taiwan)

27. I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai* ,Yi-Ching Wang* 2019/02. SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes. 7, Journal of Biomedical Science, 26:20 (SCI. IF:3.4 Cell biology, 91/190, 47.89%; Medicine, research and experimental. 46/133, 34.58%. Taiwan) (代表作)

28. Jayu Jen, Chun-Yen Liu, Yu-Ting Chen, Li-Ting Wu, Yang-Chih Shieh, Wu-Wei Lai & Yi-Ching Wang. 2019/02 Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression. Cell Death & Differentiation.26;1283–1298. (SCI: 8.0, Biochemistry & molecular biology, 26/293, 8.87%; Cell biology. 29/190, 15.26%. England)

29. Szu-Chun Yang, Chin-Wei Kuo, Wu-Wei Lai, Chien-Chung, Lin, Wu-Chou Su, Sheng-Mao Chang, Jung-Der Wang. 2019/07. Dynamic Changes of Health Utility in Lung Cancer Patients Receiving Different Treatments: A 7-Year Follow-up. J Thorac Oncol 14(11),1892-1900 [SCI impact factor: 12.6, Q1].

30.  Sheng-You Liao, I-Ying Kuo, Yu-Ting Chen, Pao-Chi Liao, Ya-Fen Liu, Hsin-Yi Wu, Wu-Wei Lai & Yi-Ching Wang. 2019/08. AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression. Oncogene 38, 6723–6736.

31.  Po-Lan Su, Szu-Chun Yang, Yi-Lin Chen, Yi-Lin Wu, Chia-Ying Lin, Wei-Yuan Chang, Yau-Lin Tseng, Wu-Wei Lai, Chung-Liang Ho, Chien-Chung Lin, Wu-Chou Su. 2019/08. Real-world outcomes of NSCLC patients receiving tissue or circulating tumor DNA-guided osimertinib treatment. Cancer Medicine 8(6).

32. Chao-Chun Chang, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen. 2019/09. Division of inferior pulmonary ligament did not impact on the postoperative recovery or recurrence in patients undergoing video-assisted thoracoscopic surgery for primary spontaneous pneumothorax. Video-Assisted Thorac Surg. 4:20

33.  Tsung-Lun Tsai, Min-Hsin Huang, Chia-Yen Lee, Wu-Wei Lai. 2019/10. Data Science for Extubation Prediction and Value of Information in Surgical Intensive Care Unit. J. Clin. Med. 2019, 8, 1709; doi:10.3390/jcm8101709.

34. Min-Hsin Huang, Yi-Chih Wang, Shao-Chieh Lin, Wu-Wei Lai. 2019/11. New-onset atrial fibrillation in patients admitted to intensive care unit after receiving tumor resection surgery for colorectal cancer. Asian J Surg. 43(1), DOI: 10.1016/j.asjsur.2019.10.009

35. Wei-Li Huang, Ying-Yuan Chen, Chao-Chun Chang, Yi-Ting Yen, Wu-Wei Lai, Bo-Wen Lin, Jenq-Chang Lee, Yau-Lin Tseng. 2020/01 Pulmonary metastasectomy for colon and rectal cancer: Prognosis analysis disaggregated by the origin of the primary tumor.   Asian J Surg. pii: S1015-9584(20)30009-9. doi: 10.1016/j.asjsur.2020.01.004.

36.  Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Forn-Chia Lin. 2020/02. Pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy for esophageal cancer. 2020/02. Radiation Oncology 15:48.

37. Hsin-Yi Wu, Yu-Yi Pan, Arthur T. Kopylov, Victor Zgoda, Mi-Chia Ma, Ching-Hsun Wang, Wu-Chou Su, Wu-Wei Lai, Pin-Nan Cheng, Pao-Chi Liao. 2020/02. Assessment of Serological Early Biomarker Candidates for Lung Adenocarcinoma by using Multiple Reaction Monitoring-Mass Spectrometry. Proteomics Clinical Applications.

38.Wu-Wei Lai, Chia-Ni Lin, Chao-Chun Chang, Jung-Der Wang. Lifetime risks, expected years of life lost, and cost-per-life year of esophageal cancer in Taiwan. 2020/02. Scientific Reports 10(1):3722.