姓名: 李政昌 醫師
主要學歷

現職

經歷

專長

學術成大

學術論文

1. Lai HS, Lee JC, Chen WJ, et al: A review of 123 abdominal tumors in children. J Surg Assoc R.O.C.  21(5):561-568,1988
2. Chen WJ, Lee JC, and Hung WT: Primary Malignant tumors of liver in infants and Children in Taiwan. J of pediatric Surgery（SCI） 23(5):457-461,1988
3. Lee JC, Lai HS, Chen WJ et al: Primary malignant tumors of the liver in childhood: Ten-year experience at the National Taiwan University Hospital J Formasan Med Assoc （SCI）87:206-211,1988 (First author)
4. Huang SM, Taso CJ, Jin YT, Chang KJ, Lee JC, and Lin PW: Immune alteration in adult patients Splenectomized for trauma.  J Surg Asso ROC 23(4):301-305,1990
5. Chang TW, Chan SH, Huang TJ, Lin PW, Lee PC, Huang SM, Lee JC, Yang YJ. Nonoperative Treatment for Blunt Splenic Injuries in Adults: Clinical Parameters Predicting Successful Results.  J Surg Assoc R.O.C. 26(3):1744-1751,1993
6. Lee JC, Lin PW, Huang SM et al : Serum lymphocyte subpopulations and Immunoglobulins in Gastric Cancer patients,  J Surg Assoc R.O.C. 26(3) 1752-1758,1993
7. Lee WY, Tzeng CC, Jim YT, Chow NH, Yip CM and Lee JC: Papillary Cystic Tumor of Pancreas: A case Indistinguishable from Oncocytic Carcinoma.  Pancreas （SCI）1:127-132,1993
8. Lee JC, Pillsi S: Complete Nucleotide Sequence of MHC class I Alleles in the Ht 29 colon Cancer Cell line. Tissue Antigen （SCI）42:530-532,1993 (First author)
9. Aoki Y, Lee JC, and Pillai S, et al: Radiolabelled polymerase chain reaction assay for the detection of ras Oncogene point mutation in tumor.  Clinical Chemistry （SCI）40(5):705-709,1994
10. Yin WY, Lin PW, Huang SM, Lee PC , Lee JC, Chang TW: Bezoar manifested with intestinal obstruction.  A review of 20 cases.  J Surg Assoc ROC 27(1):2189-2197,1994.
11. Chen CL, Huang SM, Chien CH, Chang TT, Yu CY and Lee JC: Successful resection of a minute icteric hepatocellular carcinoma.  Hepato- Gastroenterol （SCI）vol.5(41); 503-505,1994
12. Lee JC, Chow NH, Cheng YT, Tzeng CC, Lai MD: Analysis of K-ras gene mutation and DNA ploidy status from paraffin-embedded colorectal cancer tissue sections.  JS CRS 5(2) 40-47,1994
13. Lee JC, Lai HS, Huang SM, Chang CJ, Wang CJ, Wang ST and Chen WJ: Hyperammonemic encephalopathy due to essential amino acid hyperalimentation.  J Formosan Med Assoc （SCI）93(6): 486-491,1994
14. Lee JC, Lai HS, Chen WJ, Wang ST, and Chen CJ: Serum Amimo Acid Pattern in Total Parenteral Nutrition eith Essential Amimo Acids as the Sole Notrogen Source.  J Surg Assoc R.O.C 28(5):341-348,1995
15. Yong HB,Hsu PI, Lee JC, Chan SH, Lin XZ and Chow NH: Adenoma- carcinoma sequence: A reappraisal with immunohistochemical expression of ferritin.  Journal of Surgical Oncology （SCI）60:35-40,1995
16. Lee JC, Lin PW, Lin YJ, Lai J, Yang HB and Lai MD: Analysis of K-ras gene mutation in periampullary cancers, gall bladder cancer and cholangiocarcinomas from paraffin-embedded tissue sections.  J Formosan Med Assoc （SCI）94(2):719-723,1995
17. Tai YS, Lin PI, Chen CJ, Lee JC, Iung CJ.  Papillary cystic tumor of the pancreas-Report of six cases and a review of the literature.  J Surg Assoc ROC 28:291-296,1995
18. Shan YS, Lee JC, Lin PI, SU II, Yang HE.  A rare abdominal Actinomycetoma mimicking invasive colon carcinoma-A case report.  J Surg Assoc ROC 29:244-248,1996
19. Lee JC, Sang WT, Lai MD, Lin YJ and Yang HB: K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.  Anticancer Research（SCI） 16(6):3839-3844,1996
20. Lee JC, Lee TS, Ho HY, Hsueh HC, Huang WT, Ho YR and Lai MD: Expression pattern of nuclear p53 is uniqe in COS-1 cells. Anticancer Research （SCI）16(5):2705-2708,1996
21. Yang HB, Hsu PI, Chan SH, Lee JC, Shin JS and Chow NH: Growth kinetics of colorectal adenoma-carcinoma sequence . An immunohistochemical study of pro-liferating cell nuclear antigen expression.  Human Pathology（SCI） 27(10):1071-1076,1996
22. Yin WY, Lin PW. Huang SM, Lee PC, Lee JC, Chang TW and Yang YJ: Bezoar manifested with digestive and biliary obstruction.  Hepatogastroenterol, （SCI）44:1037-1045,1997
23. Chen SG, Lee JC, Lin PW. Small bowel volvulus caused by massive ingestion of elemental mercury.  J Surg Asso ROC 30(1):48-50,1997
24. Lin PW, Lee JC, Lee PC, Chang TW, Huang CT, and Chang YC.  A simple, secure and universal pancreaticojejunostomy following pancreatic duodenectomy. HPB Surgery 10:305-310,1997
25. Lee JC, Chow NH, Wang ST and Huang SM:（First author and Corresponding）Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients,  European Journal of Cancer, （SCI）36:748-753,2000
26. Huang SM, Lee JC, Chow NH.  Clinical relevance of vascular endothelial growth factor for thyroid carcinoma.  World Journal of Surgery ,（SCI）25:302-306,2001
27. Lee JC, Lin YJ, Chow NH and Wang ST:（First author and Corresponding）Reappraisal of the role of NM23-H1 in colorectal Cancers .Journal of Surgical Oncology （SCI）76:58-62,2001
28. Lin JH , Chen WC ,Hsu MM ,Hsiao CJ.Sheu BS , Lee JC . Cutaneous manifestations of Cronkhite- Canada Syndrome – A case report   Dermatologica Sinica .19（1）:288-294,2001
29. Andreyev HJN, Norman AR,……………………Lee JC, Wang ………..and Urosevic N.Kirsten ras mutations in patients with colorectal cancer :the 〝RASCAL II〞study .（Presented by the Kirsten ras in-colorectal –cancer collaborative group （Coauthor）Birtish Journal of Cancer （SCI）85（5）:692-696,2001
30. Shan YS, Yan JJ , Sy ED, Jin YT and Lee JC （Corresponding author）:Nested polymerase chain reaction in the diagnosis of negative Zieehl-Nelsen stained Mycobacterium Tuberculosis fistula in ano  Disease of the Colon and Rectum（SCI）45:1685-1688,2002
31. Lee JC , Wang ST ,Chow NH , Yang HB .（Firse Author and corresponding）Investigation of prognostic value of coexpressed erb B family members in survival of colorectal cancers after curative surgery .European Journal of Cancer（SCI）38:1065-1071,2002
32. Lee SC , Fung CP , Chen HY ,Li CT ,Jwo SC, Hung YB , See LC , Liao HC , Loke SS ,Wang FL , Lee JC .Candida peritonitis due to peptic ulcer perforation :Incidence rate , risk factors , prognosis and susceptibility to fluconaole and amphotericin B. Diagnostic Microbiology and infectious disease（SCI）44（1）:23-27,2002
33. Day SH, Lin YC, Tsai ML, Tsao LT, Ko HH, Chung MI, Lee JC, Wang JP, Won SJ, Lin CV.  Potent cytotoxic ligands from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophage.  Journal of Natural Products.  65:(3):379-381. 2002 Mar
34. Yeh IC, Chen HHW, Lee JC ,Su WC, Tsai HM, Leung HWC. Preoperative radiotherapy and chemotherapy for low locaclly advanced rectal cancer. Therapeut Radiol Oncol 10（1）:27-36 ,2003.
35. Shan YS , Lee JC ,Chow NH ,Yang HB and Wang ST （Corresponding author）: Immunohistochemical microvessel count is not a reliable prognostic predictor in colorectal carcinoma.   Hepato-Gastroenterology （SCI）50:1316-1320,2003
36. Lee JC, Chen MJ, Chang Ch , Tiai YF , Lin PW ,Lai HS Wang ST :（First author and Corresponding）Plasma amino acid levels in patients with colorectal cancers and liver cirrhosis with hepatocellular carcinoma . Hepatogastroenterol（SCI）50:1269-1273,2003
37. Lin BW , Lee JC （Corresponding author）Adult intussusception – Analysis of 15 cases J Soc colon Rectal Surgeon （Taiwan）14:1-6,2003
38. Andreyev HJN ,Benaouzig R…………………Lee JC , Wang ST ………..Ward R . Mutant K-ras 2 in serum   Gut （SCI）52:915-916,2003
39. Shan YS , Hsu HP ,Hsieh YH , Sy ED , Lee JC , Lin PW.  Significance of intraoperative peritoneal culture of fungus in perforated peptic ulcer British Journal of Surgery （SCI）90:1215-1219,2003
40. Tseng KC , Sheu BS Lee JC ,Tsai HM , Chiu NT and Dai YC : （Corresponding author）Application of 99m TC human serum albumin scan to assist surgical treatment of protein-losing enteropathy in Cronkhite-Canada Syndrome-Report of a case  Disease of the Colon and Rectum（SCI）48:870-873,2005
41. Lee JC, Maa MC, Yu HS, Wang JH, Yen CK ， Wang ST,  Jin YT ,and Leu TH : Butyrate regulates the expression of C-SRC and focal adhesion kinase and inhibits cell invasion of human colon cancer cells .Molecular Carcinogenesis.（NSC87-2314-B-006-044）（SCI）43:207-214, 2005
42. Lee JC , Lee CH , Su CL , Huang CW , Liu HS , Lin CN , and Won SJ： Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis（SCI） 26:1716-1730,2005（NSC90-2314-B-006-123）
43. Lai HS , Lee JC , Lee PH , Wang ST , Chen WJ  : Plasma free amino acid profile in cancer patients . （Corresponding author）Seminars in Cancer Biology（SCI） 15: 267-276 ，2005
44. Lai CH , Shan YS, Sy ED, Hsieh YH , Tsai HW , Lee JC, Lin PW :The Significance of CD44 Expression in Gastrointestinal Neuroendocrine Tumors. Hepato-Gastroenterology （SCI）52:1071-1076 ,2005
45. Huang WT, Chang KC, Tsao CJ, Lee JC : Successfu initial treatment with ewwkly 24-hour infusion of 5-fluorouracil and leucovorin in a rectal cancer patient with acute disseminated intravascular coagulation. Hepato-Gastroenterology （SCI）. 52（65）:1436-1439,2005（Corresponding author）
46. Shan YS, Lee JC: Early Presumptive Therapy with Fluconazole for Occult Candida Infection after Gastrointestinal Surgery. World Journal of Surgery（SCI）30:119-26，2006（Corresponding author）
47. Chen CY, Cheng CH, Chen YC, Lee JC, Chou SH, WH , Chuang CY: Preparation of Amino-Acid-Type Selective Isotope Labeling of Protein Expressed in Pichia Pastoris.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS （SCI）62:279-287,2006
48. Sua CL, Huang LLH, Huang LM, JC Lee, Lind CN, Wone SJ: Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells. FEBS Letters （SCI） 580 (13): 3185-3191 ,2006
49. MC Maa, JC Lee, YJ Chen, Y-J Chen, YC Lee, STr Wnag, CC Huang, NH Chow, TH Lue: EPS8 Facilitated Cellular Growth and Motility of Colon Cancer Cells by Increasing the Expression and Activity of Focal Adhesion Kinase.   Journal of Biological Chemistry （SCI）28:19399-19409,2007
50. Chun-Li Su, Chun-Chun Cheng, Mao-Tsun Lin, Hsiao-Chun Yeh, Meng-Chou Lee, Jenq-Chang Lee, Shen-Jeu Won. Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B.The FEBS journal 2007;274(14):3633-45.
51. CT Lee, NH Chow, PF Su, SC Lin PC Lon, JC Lee : The Prognostic Significance of RON and MET Receptor Co-expression in Colorectal Cancer Patients. Disease of the Colon and Rectum（Corresponding author） （SCI）51:1268-1274,2008
52. JC Lee, SJ Won, CL Chao , FL Wu,HS Liu , P Ling, CN Lin , C-L Su : Morusin induces apoptosis and suppresses NF-κB activity in human colorectal cancer HT-29 cells. Biochemical and Biophysical Research（SCI）  372:236-242,2008 (First author)
53. CW Chien, SC Lin,YY Lai, BW Lin ,SC Lin, JC Lee, SJ Tsai :Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clinical Cancer Research（Co-Corresponding author）（SCI）14 (24), 8043-8050,2008
54. JC Lee, CL Su, LL Chen, SJ Won: Formosanin C-induced apoptosis requires activation of caspase-2 and change mitochondrial membrane potential. Cancer Science （SCI）100(3),503-513,2009(First author)
55. SC Lin, E Sy, BW Lin, JC Lee: Management of Colorectal Anastomotic
Strictures Using Multidiameter Balloon Dilation. J Soc Colon Rectal Surgeon ROC（Corresponding author）,20(3)62-68,2009
56. YS Tseng, JC Lee CY F Huang, HS Liu : Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway BMC Cancer（SCI） 2009, 9:435 doi:10.1186/1471-2407-9-435
57. Lai CH, Tseng JT, Lee YC, Chen YJ, Lee JC, Huang TC, Liu YW, Leu TH, Liu YW, Chen YP, Chang WC, Hung LY : Translational up-regulation of Aurora-A in EGFR-overexpressed cancer  J Cell Mol Med. （SCI） 2010 Jun;14(6B):1520-1531
58. YH Feng. CJ Tsao. CL Wu. JG Chang. PJ Lu. KT Yeh. GS Shieh. AL Shiau. JC Lee: Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells . Cancer Sci.2010（SCI）, 101(9)2033-2038（Co-Corresponding author）
59. SC Lin, Bn Lin, WW Lai, YL Tseng, MH Wu, JC Lee. Surgical management of pulmonary metastases of colorectal cancer. J Soc Colon Rectal Surgeon (Taiwan). 2010,21:130-137
60. YH Feng. CL Wu. CJ Tsao. JG Chang. PJ Lu. KT Yeh. YH Uen. JC Lee. AL Shiau: Deregulated Expression of Sprouty2 and MicroRNA-21 in Human Colon Cancer: Cancer Biology & therapy.2011;11(1):111-121（SCI）（Co-Corresponding author）
61. WC Chen , SC Lin , JC Lee : A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer. Kaohsiung Journal of Medical Sciences（SCI） (2011) 27, 68-71（Corresponding author）
62. SC Lin, CW Chien, JC Lee, YC Yeh, KF Hsu, YY Lai, SC Lin, SJ Tsai.
Suppression of dual-specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells. Journal of Clinical Investigation . 2011;121: 1905-1916 (SCI)
63. CW Lu, SC Lin, CW Chien, SC Lin, CT Lee, BW Lin, JC Lee, SJ Tsai.: Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol. 2011;179:1405-14.. (SCI) (Co-Corresponding author）
64. PC Lin, SC Lin, CT Lee, Y Lin, and JC Lee.: Dynamic Change of Tetraspanin CD151 Membrane Protein Expression in Colorectal Cancer Patients. Cancer Investigation. 2011;29: 542-547 (SCI) （Corresponding author）
65. JH Tsou, KC Chang. PY Chang-Liao, ST Yang, CT Lee, YP Chen, YC Lee, BW Lin, JC Lee, MR Shen, CK Chuang, WC Chang, JM Wang, LY Hung. : Aberrantly expressed AURKC enhances the transformation and tumorigenicity of epithelial cells. Journal of Pathology. 2011;225:243-254 (SCI)
66. CH Liu, CH Chen, JC Lee , :Rehabilitation Exercise on the Quality of Life in Anal Sphincter-Preserving Surgery. Hepato-Gastroenterology 2011; 58:110-111 (SCI)
67. Ching-Hsiang Liu, Ching-Huey Chen, Jenq-Chang Lee. Rehabilitation exercise on the quality of life in anal sphincter-preserving surgery. Hepato-gastroenterology. 2011;58(110-111):1461-5.
68. PC Chen, WC Chen, SC Chao, BW Lin, SC Lin, CJ Chen, JC Lee.: Six Primary Cancers in One Lynch Syndrome Patient With Chronic Arsenic Exposure. Journal of Surgical Oncology. 2012;105:329-330 (SCI) (Corresponding author）
69. PC Chen, SC Chao, KF Hsu, CT Lee, J-C Lee.: Endometrioid adenocarcinoma arising from colonic endometriosis in a Lynch syndrome patient. International Journal of Colorectal Disease. 2012;27:681-682 (SCI) (Corresponding author）
70. L C, PC Lin, J S.Chang, PY Chu, PK Lee, SN Chen, YM Cheng, JC Lee, JY Chang, TW Liu.: Differences in the Frequencies of K-ras c12-13Genotypes by Gender and Pathologic Phenotypes in Colorectal TumorsMeasured Using the Allele DiscriminationMethod. Environmental and Molecular Mutagenesis. 2012;53:22-31 (SCI)
71. CT Lee, NH Chow, YS Liu, SC Lin, PC Lin, YH Wu, JC Lee, HM Tsai.: Computed Tomography with Histological Correlation for Evaluating Tumor Regression of Rectal Carcinoma after Preoperative Chemoradiation Therapy Hepato-Gastroenterology 2012; 598:2484-2489 (SCI)
72. Y-H Feng , CL Wu, AL Shiau, JC Lee, JG Chang, PJ Lu, CL Tung, LY Feng, WT Huang, CJ Tsao.：MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. Int J Mol Med. 2012;29:920-926
73. CC Chen, JC Lee, MC Chang.： 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2. FEBS Letters, 2012;586: 2260-2266
74. YC Chen, CH Cheng, YS Chang, YT Chang, CH Huang, JC Lee, JH Shiu, WJ Chuang.： Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin. Toxicon : official journal of the International Society on Toxinology 2012;60(8):1342-8.
75. SC Lin, PC Chen, CT Lee, HM Tsai, PC Lin, Helen, H.W. Chen, YH Wu, BW Lin, WP Su, JC Lee.： Routine defunctioning stoma after chemoradiation and total mesorectal excision: a single-surgeon experience. World Journal of Gastroenterology. 2013;19(11): 1797-1804. (Corresponding author）
76. S-T Yang, C-J Yen, K-C Chang, W-C Chang, P-Y Chang-Liao, L-S Hsu, W-C Hung, C-H Lai, J-C Lee, Y-J Lin, Y-W L, Y-W Liu, T K Tang, Li-Y Hung: SUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC. Journal of hepatology 2013;58:1157-64.
77. JA Ju, CT Huang , SH Lan, TH Wang , P-C Lin , JC Lee, YF Tian, HS Liu. Characterization of colorectal cancer migration and autophagy related microRNA miR-338-5p and its target gene PIK3C3. Genomic Medicine, Biomarkers, and Health Sciences. Genomic Medicine, Biomarkers, and Health Sciences. 2013;5:74-78
78. PC Lin, YJ Lin, CT Lee, HS Liu, JC Lee. Cyclooxygenase-2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. Oncol Lett. 2013;6: 733-739 (Corresponding author）
79. Yen-Chien Lee, Yen-Lin Lee, Jen-Pin Chuang, Jenq-Chang Lee. Differences in Survival Between Colon and Rectal Cancer from SEER Data. PLOS ONE 2013;8: e78709 (Corresponding author）
80. FC Wen, JC Lee. hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial-mesenchymal transition through inhibition of Slug transcription. Carcinogenesis 2014 35(7):1481-90.(Corresponding author）
81. Bo-Wen Lin, Yu-Chu Wang, Pey-Yi Chang-Liao, Ya-Ju Lin, Shu-Ting Yang, Jen-Hui Tsou, Kung-Chao Chang, Yao-Wen Liu, Joseph T. Tseng, Chung-Ta Lee, Jenq-Chang Lee and Liang-Yi Hung. Overexpression of Aurora-C impaired the spindle checkpoint by promoting the degradation of Aurora-B. Cell Death and Disease 2014;5(3): e1106 (Corresponding author）
82. Shao-Chieh Lin, Wan-Lin Liao, Jenq-Chang Lee, and Shaw-Jenq Tsai. Hypoxia-regulated Gene Network in Drug Resistance and Cancer Progression. Experimental Biology and Medicine 2014; 239(7):779-792 (Corresponding author）