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1. Weihsun Lu, Hong-Ming Tsai, Ying-Jui Chao, Ting-Kai Liao, Yan-Shen Shan*. Pancreatic regeneration and changes in endocrine function after pancreatectomy. 2019 (submitted)
2. Chien-Hsien Yeh, Fong-Chin Su, Yan-Shen Shan, Marat Dosaev, Yury Selyutskiy, Irina Goryacheva, Ming Ju. Application of Piezoelectric Actuator to Simplified Haptic Feedback System. Sensors & Actuators: A. Physical. 2020 Mar 1, vol 303: 111820 (Accepted).
3. Chang-Fang Chiu, Jing-Ru Weng, Shou-Lun Lee, Chia-Yung Wu, Po-Chen Chu, Yan-Shen Shan, Horng-Ren Yang, Li-Yuan Bai*. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels. Biochemical Pharmacology 2020 Jan 16:113811. doi: 10.1016/j.bcp.2020.113811
4. Ying-Jui Chao, Yu-Lun Chen, Ya-Chin Hou, Hao-Chen Wang, Pei-Jung Lu, Yan-Shen Shan*. Poor clinicopathologic role of TBC1D23 in non-small cell lung and its potential pathway by bioinformatics analysis. OncoTarget and Therapy 2019 (Revised).
5. Ming-Huang Chen, Wen-Chi Chou, Chin-Fu Hsiao, Shih-Sheng Jiang, Hui-Jen Tsai, Yi-Chang Liu, Chiun Hsu, Yan-Shen Shan, Yi-Ping Hung, Chia-Hsun Hsich, Chao-Hua Chiu, Ta-Chih Liu, Shih-Feng Cho, Tsang-Wu Liu, Yee Chao. An Open-Label, Single-Arm, Two-Stage, Multicenter, Phase II Study to Evaluate the Efficacy of TLC388 and Genomic analysis for Poorly Differentiated Neuroendocrine Carcinomas. Oncologist. 2019 Dec 18. doi: 10.1634/theoncologist.2019-0490.
6. Hsu CC, Liao WY, Chan TS, Chen WY, Lee CT, Shan YS, Huang PJ, Hou YC, Li CR, Tsai KK. The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis. J Pathol. 2019 Aug 29. doi: 10.1002/path.5341.
7. Divinah Manohran, Li-Chan Chang, Liu-Chun Wang, Yan-Shen Shan, Forn-Chia Lin, Lai-Chin Wu, Hwo-Shuenn Sheu, Wen-Pen Su, Chen-Sheng Yeh. Low-dose X-ray-excited integrated scintillating nanoparticles enhanced X-ray therapy in controlled chemotherapy with highly targeting pancreatic tumor showing synergistic effect. JACS 2020 (revised)
8. Yan-Shen Shan et al. Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan. 2019 (submitted).
9. Priya Gopinathan, Nai-Jung Chiang, Anandaraju Bandaru, Anirban Sinha, Wen-Yen Huang, Shang-Cheng Hung#, Yan-Shen Shan#, Gwo-Bin Lee#. Exploring circulating tumor cells in cholangiocarcinoma using a novel glycosaminoglycan probe on a microfluidic platform. 2019 (submitted)
10. Ya-Chin Hou, Ching-Cheng Hsu, Hui-Ling Tung, Min-Hua Hsieh, Hao-Chen Wang, Yi-Ching Wang, and Yan-Shen Shan*. Rab37 mediates exosomal osteopontin secretion to promote pancreatic cancer metastasis and stemness. 2020 (submitted)
11. Chia-Lung Yang, Ying-Jui Chao, Hao-Chen Wang, Ya-Chin Hou, Gong-Shen Chen, Chia-Ching Chang, Yan-Shen Shan.* Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying demethylation drugs. NBM 2020 (revised)
12. Yung-Yeh Su, Nai-Jung Chiang, Hui-Jen Tsai, Chia-Jui Yen, Yan‐Shen Shan*, Li‐Tzong Chen. Efficacy of Nanoliposomal Irinotecan and Impact on Survival of Advanced Pancreatic Ductal Adenocarcinoma: A Single Institutional Experience. Sci Rep 2019 (Revised)
13. Hui-Ju Ch’ang, Yen-Feng Chiu, Jen-Hsi Chen, Chung-Pin Li, Ching-Liang Ho, Yi-Ming Shyr, Wen-Chi Chou, Chun-Nan Yeh, Ruey-Kuen Hsieh, Yu-Lin Lin, Yu-Wen Tien, Tsann-Long Hwang, Yan-Shen Shan*, Li-Tzong Chen, on behalf of the Taiwan Cooperative Oncology Group pancreatic cancer study group. Randomized Phase III Study Comparing Adjuvant Gemcitabine versus Gemcitabine plus Chemoradiation in Curatively Resected Pancreatic Cancer. 2019 (submitted)
14. Yung-Jue Bang, Chung-Pin Li, Kyung-Hun Lee, Chang-Fang Chiu, Joon Oh Park, Yan-Shen Shan, Jun Suk Kim, Jen-Shi Chen, Hyun-Jeong Shim, Kun-Ming Rau, Hye Jin Choi, Do‑Youn Oh, Bruce Belanger, Li-Tzong Chen. Liposomal irinotecan in metastatic pancreatic adenocarcinoma in Asian patients: subgroup analysis of the NAPOLI-1 study. Cancer Science 2019 Dec 1. doi: 10.1111/cas.14264.
15. Margaret A. Tempero, Hanno Riess, Uwe Pelzer, Eileen O'Reilly, Jordan Winter, Do-Youn Oh, Chung-Pin Li, Giampaolo Tortora, Heung-Moon Chang, Charlie Lopez, Tanios Bekaii-Saab, Andrew Ko, Armando Santoro Joon Oh Park, Marcus Noel, Giovanni Luca Frassineti, Yan-Shen Shan, Mingyu Li, Stefano Ferrara, Brian Lu Andrew Dean, Michele Reni, on behalf of the APACT investigators. Phase III Multicenter, International, Open-Label, Randomized Trial of Adjuvant nab-Paclitaxel (nab-P) plus Gemcitabine (Gem) vs Gem Alone for Surgically Resected Pancreatic Adenocarcinoma 2019 (submitted)
16. Nai-Jung Chiang, Kelvin K. Tsai, Chin-Fu Hsiao, Shih-Hung Yang, Hui-Hua Hsiao, Wen-Chi Shen, Chiun Hsu, Yu-Lin Lin, Jen‐Shi Chen, Yan-Shen Shan*, Li-Tzong Chen. A Multicenter, Phase I/II Trial of Biweekly S-1, Leucovorin, Oxaliplatin and Gemcitabine in Metastatic Pancreatic Adenocarcinoma -TCOG T1211 Study. Eur J Cancer. 2019 Nov 22;124:123-130.
17. Hao-Chen Wang, Yung-Lun Lin, Ching-Cheng Hsu, Ying-Jui Chao, Ya-Chin Hou, Tai-Jan Chiu, Po-Hsien Huang, Ming-Jer Tang, Li-Tzong Chen, Yan-Shen Shan*. Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8. Theranostics 2019 Sep 23;9(24):7168-7183.
18. Yuan-Shuo Hsueh, Hui Hua Chang, Yan-Shen Shan, H. Sunny Sun, Jonathan Alfred Fletcher, Chien-Feng Li, Li-Tzong Chen. Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors. Oncogene 2019 Sep; 38(38):6550-6565.
19. Weng CC, Hsieh MJ, Wu CC, Lin YC, Shan YS, Hung WC, Chen LT, Cheng KH. Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer. Mol Cancer. 2019 May 20;18 (1):96.
20. Ya-Chin Hou, Ying-Jui Chao, Min-Hua Hsieh, Hui-Ling Tung, Hao-Chen Wang, and Yan-Shen Shan*. Low CD8+ T cell infiltration and high PD-L1 expression are associated with CD44+/CD133+ cancer stem cells and predict an unfavorable prognosis in pancreatic cancer. Cancers (Basel). 2019 Apr 15;11(4)
21. Ming-Chuan Hsu; Ya-Li Tsai; Chia-Hsien Lin; Mei-Ren Pan; Yan-Shen Shan; Tsung-Yen Cheng; Skye Hung-Chun Cheng; Li-Tzong Chen; Wen-Chun Hung. Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. Journal of Hematology & Oncology 2019 Jul 19;12(1):79.
22. Jeffrey S. Chang, Sung-Hsin Kuo; Pei-Yi Chu; Yan-Shen Shan; Chia-Rung Tsai; Hui-Jen Tsai; Li-Tzong Chen. The epidemiology of gastric cancers in the era of Helicobacter pylori eradication: a nation-wide cancer registry-based study in Taiwan. Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1694-1703.
23. Wang CJ, Lin SY, Tsai SH, Shan YS. Implications of long-term low-fidelity in situ simulation in acute care and association with a reduction in unexpected cardiac arrests: A retrospective research study. PLoS One. 2019 Mar 12;14(3):e0213789.
24. Tsui-Mai Kao, Yi-Sheng Liu, Yan-Shen Shan, Hu-Ju Ch'ang, Li-Tzong Chen. Cure of unresectable locally advanced pancreatic cancer after multidisciplinary therapy. J Cancer Research & Practice. 2018 (0n line)
25. Lee KT, Chang CL, Li CY, Song H, Shan YS, Lai MD. The oncogenic role of MST3 in human gastric cancer. Am J Cancer Res. 2018 Oct 1; 8(10): 2130-2139.
26. Chih Jung Wang, Edgar D. Sy, Ying Jui Chao, Yan Shen Shan. A Simple method of Intracorporeal “W-shaped” Liver Retraction Technique for Minimally Invasive Gastric Cancer Surgery. Surg Lap Endosc Percut Tech 2019 Jun;29(3):e24-e28.
27. Sy ED, Shan YS, Lin CH. Vitelline fistula associated with omphalocele: Diagnostic dilemma? Int J Surg Case Rep. 2018; 47: 45-47.
28. Tzu-Lei Kuo, Kuang-Hung Cheng, Yan-Shen Shan, Li-Tzong Chen, Wen-Chun Hung. β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer. Theranostics 2019 Jan 1; 9(2): 324-336.
29. Hsin-Hsien Yu, Yutaka Yonemura, Mao-Chih Hsieh, Chang-Yun Lu, Szu-Yuan Wu, Yan-Shen Shan* Experience of applying cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for ovarian teratoma with malignant transformation and peritoneal dissemination. Therapeutics and Clinical Risk Management. 2019; 15: 129-136.
30. Hsin-Hsien Yu, Mao-Chih Hsieh, Szu-Yuan Wu, Edgar D. Sy, Yan-Shen Shan*. Effects of Duodenal–Jejunal Bypass Surgery in Ameliorating Nonalcoholic Steatohepatitis in Diet-Induced Obese Rats. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019; 12:149–159.
31. Ming-Chuan Hsu, Mei-Ren Pan, Pei-Yi Chu, Ya-Li Tsai, Chia-Hua Tsai, Yan-Shen Shan, Li-Tzong Chen, Wen-Chun Hung * Protein arginine methyltransferase 3 enhances chemoresistance in pancreatic cancer by methylating hnRNPA1 to increase ABCG2 expression. Cancers 2018 Dec 20; 11(1). pii: E8. doi: 10.3390/cancers11010008.
32. Ya-Chin Hou, Chih-Jung Wang, Ying-Jui Chao, Hao-Yun Chen, Hao-Chen Wang, Hui-Ling Tung, Jung-Ting Lin, Yan-Shen Shan*. Elevated serum Interleukin-8 level correlates with cancer-related cachexia and sarcopenia: an indicator for pancreatic cancer outcomes. JCM 2018 Dec 1;7(12). pii: E502. doi: 10.3390/jcm7120502.
33. Chen LT, Siveke JT, Wang-Gillam A, Li CP, Bodoky G, Dean AP, Shan YS, Jameson GS, Macarulla T, Lee KH, Cunningham D, Blanc JF, Chiu CF, Schwartsmann G, Braiteh FS, Mamlouk K, Belanger B, de Jong FA, Hubner RA. Survival with nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil and leucovorin in per-protocol and non-per-protocol populations of NAPOLI-1: Expanded analysis of a global phase 3 trial. Eur J Cancer. 2018 Nov 7; 105: 71-78.
34. Yang TH, Chen JL, Lin YJ, Chao YJ, Shan YS, Hsu HP, Su ZM, Chou CC, Yen YT. Laparoscopic surgery for large left lateral liver tumors: safety and oncologic outcomes. Surg Endosc. 2018 Oct; 32(10): 4314-4320.
35. Hsin-Hsien Yu, Chia-Lun Chang, Kevin Sheng-Po Yuan, Alexander T.H.Wu, Yan-Shen Shan*, Szu-Yuan Wu *. Fucoidan inhibits radiation-induced pneumonitis and lung fibrosis by reducing inflammatory cytokine expression in lung tissues. Mar Drugs. 2018 Oct 19;16(10) pii: E392. doi: 10.3390/md16100392.
36. Jeffrey. S. Chang; Li-Tzong Chen; Yan-Shen Shan; Pei-Yi Chu; Chia-Rung Tsai; Hui-Jen Tsai. The incidence and survival of pancreatic cancer by histology, including rare subtypes: a nation-wide cancer registry-based study from Taiwan. Cancer Med. 2018 Nov;7(11):5775-5788.
37. Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng, Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, Wen-Tsan Chang. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget 2018 Apr 10;9(27):18949-18969..
38. Hung YP, Chen MH, Lin JS, Hsiao CF, Shan YS, Chen YC, Chen LT, Liu TW, Li CP, Chao Y. The clinical impact of the novel tumor marker DR-70 in unresectable gastric cancer patients. J Chin Med Assoc. 2018 Jul;81(7): 593-598.
39. Lin CY, Ou MC, Liu YS, Chuang MT, Shan YS, Tsai HM, Wang CK, Tsai YS. A CT-guided fat transversing coaxial biopsy technique for pancreatic lesion biopsy that avoids major organs and vessels. Saudi J Gastroenterol. 2017; 23(6):341-347.
40. Chen CW, Cheng TJ, Ho CH, Wang JJ, Weng SF, Hou YC, Cheng HC, Chio CC, Shan YS, Chang WT. Increased risk of brain cancer incidence in stroke patients: a clinical case series, population-based and longitudinal follow-up study. Oncotarget. 2017 Nov 15; 8(65):108989-108999.
41. Pei-Yi Chu*, Shih Sheng Jiang*, Yan-Shen Shan*, Wen-Chun Hung, Ming-Huang Chen, Hui-You Lin, Yu-Lin Chen, Hui-Jen Tsai, Li-Tzong Chen. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors. Oncotarget Oct 9; 8(61):103613-103625.
42. Tsung-Ming Chang*, Yan-Shen Shan*, Pei-Yi Chu*, Shih Sheng Jiang, Wen-Chun Hung, Yu-Lin Chen, Hsu-Chi Tu, Hui-You Lin, Hui-Jen Tsai, Li-Tzong Chen. The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors. Oncotarget 2017, 8 (58):98068-83.
43. Yan-Shen Shan, Hui-Ping Hsu, Ming-Derg Lai, Yu-Hsuan Hung, Chih-Yang Wang, Meng-Chi Yen, Yi-Ling Chen. Increased expression of cyclin D1 correlates with poor tumor differentiation and predicts poor prognosis in gastric cancer patients. Oncol Lett 2017; 14: 4517-26.
44. Hao-Chen Wang, Chin-Wang Chen, Chia-Lung Yang, I-Min Tsai, Ya-Chin Hou, Chang-Jung Chen, Yan-Shen Shan*.Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells. Cancer Immunol Res. 2017, Oct; 5(10): 885-897.
45. Gopinathan P, Hung LY, Wang CH, Chiang NJ, Wang YC, Shan YS*, Lee GB*. Automated selection of aptamers against cholangiocarcinoma cells on an integrated microfluidic platform. Biomicrofluidics. 2017 Jul 5; 11(4): 044101.
46. Shu-Ting Yen, Chih-Jung Wang, Shih-Fang Huang, Su-Chen Hsu, Jeremy C. Ying*, Yan-Shen Shan*. Effectiveness of Trauma Team on Medical Resource Utilization and Quality of Care for Patients with Major Trauma. BMC Health Services Research 2017 Jul 24; 17(1):505.
47. Ching-Wen Yu, Chien-Yu Fu, Lien-Yu Hung, Chih-Hung Wang, Nai-Jung Chiang, Yu-Chun Wang, Yan-Shen Shan* and Gwo-Bin Lee*. Screening of Peptide Specific to Cholangiocarcinoma Cancer Cells Using an Integrated Microfluidic System and Phage Display Technology. Microfluid Nanofluid 2017; 21: 145.
48. Lien-Yu Hung, Nai-Jung Chiang, Wei-Chun Tsai, Chien-Yu Fu, Yu-Chun Wang, Yan-Shen Shan*, and Gwo-Bin Lee*. A microfluidic chip for detecting cholangiocarcinoma cells in human bile. Sci Rep 2017 Jun 26;7(1):4248.
49. Iwashita Y, Hibi T, Ohyama T, Honda G, Yoshida M, Miura F, Takada T, Han HS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Yoon YS, Choi IS, Huang WS, Chen KH, Watanabe M, Abe Y, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Shan YS, Ker CG, Chan DC, Wu CC, Lee KT, Toyota N, Higuchi R, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Shindoh J, Sunagawa H, Gocho T, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Tokumura H, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Mori R, Endo I, Miyazaki M, Yamamoto M. An opportunity in difficulty: Japan-Korea-Taiwan expert Delphi consensus on surgical difficulty during laparoscopic cholecystectomy.J Hepatobiliary Pancreat Sci. 2017 Apr; 24(4): 191-198.
50. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC. Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res. 2017 May 1; 23(9): 2335-2345.
51. Hibi T, Iwashita Y, Ohyama T, Honda G, Abe Y, Yoshida M, Miura F, Takada T, Han HS, Yoon YS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Choi IS, Huang WS, Chen KH, Watanabe M, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Sheen-Chen SM, Shan YS, Ker CG, Chan DC, Lee KT, Toyota N, Higuchi R, Yamamoto M, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Tokumura H, Shindoh J, Sunagawa H, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Endo I, Miyazaki M. The "right" way is not always popular: Comparison of surgeons' perceptions during laparoscopic cholecystectomy for acute cholecystitis among experts from Japan, Korea, and Taiwan. J Hepatobiliary Pancreat Sci. 2017 Jan; 24(1): 24-32.
52. Po-Hsien Huang,, Pei-Jung Lu, Li-Yun Ding, Po-Chen Chu, Chih-Chieh Tsao, Wei-Yu Hsu, Bo-Heng Chen, Pei-Rong Gu, Chung-Ta Li, OSU-NCKU pancreatic cancer study group, Sally E. Henderson, Samuel, K. Kulp, Yan-Shen Shan*, Ching-Shih Chen*. TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. Oncogene 2017 Apr 20; 36(16): 2202-2214.
53. Tze-Sian Chan, Chung-Chi Hsu, Kok-Tong Tan, Wen-Ying Liao, Shu-Ching Hsu, Vincent Pai, Wei-Yu Chen, Yan-Shen Shan, Shenq-Shyang Huang, Kuan-Ying Jiang, Chi-Rong Li, Michael Lee, Gi-Shih Lien, Valerie Weaver, and Kelvin Tsai. Metronomic Chemotherapy Prevents Therapy-induced Stromal ELR+-chemokine Paracrine Signaling for Tumor-initiating Cells. JEM 2016 Dec 12; 213(13): 2967-2988.
54. Iwashita Y, Ohyama T, Honda G, Hibi T, Abe Y, Yoshida M, Miura F, Takada T, Han HS, Yoon YS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Choi IS, Huang WS, Chen KH, Watanabe M, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Sheen-Chen SM, Shan YS, Ker CG, Chan DC, Lee KT, Toyota N, Higuchi R, Yamamoto M, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Tokumura H, Shindoh J, Sunagawa H, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Endo I, Miyazaki M. What are the appropriate indicators of surgical difficulty during laparoscopic cholecystectomy? Results from a Japan-Korea-Taiwan multinational survey. J Hepatobiliary Pancreat Sci. 2016 Sep; 23(9):533-47.
55. Pan MR, Hsu MC, Luo CW, Chen LT, Shan YS, Hung WC. The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer. Oncotarget. 2016 Sep 20; 7(38): 61136-61151.
56. Liu CT, Chen MH, Chen JS, Chen LT, Shan YS, Lu CH, Su YL, Ku FC, Chou WC, Chen YY. The efficacy and safety of everolimus for the treatment of progressive gastroenteropancreatic neuroendocrine tumors: A multi-institution observational study in Taiwan. Asia Pac J Clin Oncol. 2016 Dec; 12(4): 396-402.
57. Hung MC, Lai WW, Chen HH, Lee JC, Lin YJ, Hsiao JR, Cheng YM, Shan YS, Su WC, Wang JD. Cost effectiveness of cancer treatment in Taiwan. J Formos Med Assoc. 2016 Aug 115(8): 609-18.
58. Nai-Jung Chiang, Jang-Yang Chang, Yan-Shen Shan*, Li-Tzong Chen,*.Developing nanoliposomal irinotecan (nal-IRI, MM-398, PEP02) in the management of metastatic pancreatic cancer. Expert Opin Pharmacother. 2016 Jul;17(10):1413-20.
59. Tseng PC, Chen CL, Shan YS, Lin CF. An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells. Oncotarget. 2016 Mar 22; 7(12):15150-60.
60. Nai-Jung Chiang, Chiun Hsu, Jen‐Shi Chen, Hsiao-Hui Tsou, Ying-Ying Shen, Yee Chao, Ming-Huang Chen, Ta-Sen Yeh, Yan-Shen Shan*, Shiu-Feng Huang*, Li‐Tzong Chen*. Expression levels of ROS1/ALK/c-MET and therapeutic efficacy of cetuximab plus chemotherapy in advanced biliary tract cancer. Sci Rep 2016 May 3; 6: 25369.
61. Hao-Chen Wang, Tzu-Ying Li, Ying-Jui Chao, Ya-Chin Hou, Yuan-Shuo Hsueh, Kai-Hsi Hsu, Yan-Shen Shan*. KIT exon 11 codons 557-558 deletion mutation promotes liver metastasis through the CXCL12/CXCR4 axis in gastrointestinal stromal tumors. Clin Cancer Res. 2016 Jul 15;22(14):3477-87
62. Chen MH, Lin J, Hsiao CF, Shan YS, Chen YC, Chen LT, Liu TW, Li CP, Chao Y. A Phase II Study of Sequential Capecitabine Plus Oxaliplatin Followed by Docetaxel Plus Capecitabine in Patients with Unresectable Gastric Adenocarcinoma: The TCOG 3211 Clinical Trial. Medicine (Baltimore). 2016 Jan; 95(3):e2565.
63. Andrea Wang-Gillam, Chung-Pin Li, György Bodoky, Andrew Dean, Yan-Shen Shan, Gayle Jameson, Teresa Macarulla, Kyung-Hun Lee, David Cunningham, Jean F. Blanc, Richard Hubner, C.-F. Chiu, Gilberto Schwartsmann, Jens Siveke, Fadi Braiteh, Victor Moyo, Bruce Belanger, Navreet Dhindsa, Eliel Bayever, Daniel D. Von Hoff, Li-Tzong Chen for the NAPOLI-1 Study Group. Nanoliposomal Irinotecan with 5-Fluorouracil and Leucovorin Increased Survival in Metastatic Pancreatic Cancer After Prior Gemcitabine-based Therapy. Lancet 2016, Feb 6; 387(10018): 545-57.
64. Ya-Chin Hou, Chen-Fang Huang, Hao-Chen Wang, Yu Wu, Yan-Shen Shan*. Therapeutic efficacy of spleen-derived mesenchymal stem cells in mice with acute pancreatitis. J Stem Cell Res Ther. 2015; 5(12): 318.
65. Hong-Ming Tsai, Chiao-Hsiung Chuang, Yan-Shen Shan, Yi-Sheng Liu, Chiung-Yu Chen. Features associated with progression of small pancreatic cystic lesions: A retrospective study. World J Gastroenterol 2015; 21(47): 13309-15.
66. Wu CL, Chao YJ, Yang TM, Chen YL, Chang KC, Hsu HP, Shan YS, Lai MD. Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer. BMC Cancer 2015 Nov 16; 15(1): 903.
67. Chiang NJ, Shan YS, Hung WC, Chen LT. Epigenetic regulation in the carcinogenesis of cholangiocarcinoma. Int J Biochem Cell Biol. 2015 Oct; 67: 110-4.
68. Po-Chen Chu, Ming-Chen Yang, Samuel K. Kulp, Santosh B. Salunke, Yan-Shen Shan, Chung-Ta Lee, Ming-Derg Lai, Lawrence A. Shirley, Tanios Bekaii-Saab, and Ching-Shih Chen. Regulation of Oncogenic KRAS Signaling via a Novel KRAS-ILK-hnRNPA1 Regulatory Loop in Pancreatic Cancer Cells. Oncogenes 2016 Jul 28; 35(30): 3897-908.
69. Yan-Shen Shan, Yi-Ling Chen, Ming-Derg Lai, Hui-Ping Hsu, Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer. Oncol Rep. 2015 Jan; 33 (1):40-8.
70. Chih-Yuan Huang, Liang-Chao Wang, Chia-Hsin Pan, Yan-Shen Shan, Kuen-Jer Tsai. Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase. Int J Mol Sci. 2015 Jun 23; 16(6): 14171-80.
71. Ming-Chen Yang, Hao-Chen Wang, Ya-Chin Hou, Hui-Ling Tung, Yan-Shen Shan*. Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine. Mol Cancer 2015 Oct 12; 14(1):179.
72. Jeffrey. S. Chang, Li-Tzong Chen, Yan-Shen Shan (2nd), Sheng-Fung Lin, Sheng-Yen Hsiao, Chia-Rung Tsai, Shu-Jung Yu, Hui-Jen Tsai. Comprehensive Analysis of the Incidence and Survival Patterns of Lung Cancer by Histologies, Including Rare Subtypes, in the Era of Molecular Medicine and Targeted Therapy: A Nation-Wide Cancer Registry-Based Study from Taiwan. Medicine 2015 Jun; 94(24): e969.
73. Cheong MW, Kuo LH, Cheng YN, Tsai PJ, Ho LC, Tai HC, Chiu WT, Chen SH, Lu PJ, Shan YS, Chuang LM, Tsai YS. Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. J Mol Med (Berl). 2015 Jul; 93(7):807-18.
74. Jen-Shi Chen, Chiun Hsu, Nai-Jung Chiang, Chang-Sung Tsai, Hsiao-Hui Tsou, Shiu-Feng Huang, Li-Yaun Bai, Il-Chi Chang, Her-Shyong Shiah, Ching-Liang Ho, Chia-Jui Yen, Kuan-Der Lee, Chang-Fang Chiu, Kun-Ming Rau, Ming-Sun Yu, Youngsen Yang, Ruey-Kuen Hsieh, Yan-Shen Shan*, Yee Chao*, Li-Tzong Chen*. A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer. Ann Oncol 2015 May; 26(5):943-9.
75. Sheng-Yi Chen, Jo-Shi Lin, Huan-Ching Lin, Yan-Shen Shan, Yu-Jung Cheng, Bei-Chang Yang. Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor. Biochim Biophys Acta. 2015 May; 1853 (5): 929-39.
76. Jeffrey S. Chang, Chia-Rung Tsai, Li-Tzong Chen, Yan-Shen Shan*. Investigating the association between periodontal disease and risk of pancreatic cancer. Pancreas 2016 Jan;45(1):134-41.
77. Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai, Yan-Shen Shan*. The significance of the co-existence of osteopontin and tumor associated macrophages in gastric cancer. BMC Cancer 2015; Mar 15;15:128.
78. Yan-Shen Shan, Hui-Ping Hsu, Ming-Derg Lai, Meng-Chi Yen, Jung-Hua Fang, Tzu-Yang Weng, Yi-Ling Chen. Argininosuccinate synthetase suppression and arginine restriction inhibits metastasis of gastric cancer cell lines. Sci Rep 2015 Apr 30; 5: 9783.
79. Edgar D. Sy, Yan-Shen Shan. Abdominal Wall Hydrocele: a Rare Late Postoperative Complication of Drain Site Wound Incisional Hernia. JPS 2015 (accepted)
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